Article

The genome organizer SMC1A mediates the gene expression response in inflammation by dissociating from nuclear-speckles and redistributing to the nuclear periphery

2026-07-07

Abstract excerpt

Nuclear architectural proteins are increasingly recognized as multifunctional regulators whose roles extend well beyond static genome organization. Here we report that SMC1A, a core subunit of the cohesin complex, undergoes a striking redistribution upon inflammatory stimulation in human monocytes, dissociating from nuclear speckles and accumulating at genomic regions enriched for stress-response genes with distin...

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Literature Corpus work: dca272c7-d84d-5333-8e3b-a9f3a89a8f24
DOI: 10.64898/2026.07.06.736754

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