Article

Extensive fragmentation and re-organization of gene co-expression patterns underlie the progression of Systemic Lupus Erythematosus

2020-01-29

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship between transcriptional deregulation and genome organization remains largely unstudied. We developed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d717bf5c-84a9-5445-9eae-ae72059cebe6
DOI: 10.1101/2020.01.28.922559

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extensive fragmentation and re-organization of gene co-expression patterns underlie the progression of Systemic Lupus ErythematosusDOI 10.1101/2020.01.28.922559Read

Extensive fragmentation and re-organization of transcription in Systemic Lupus ErythematosusSemantic proximity Read

Cell-type-specific transcriptome architecture underlying the establishment and exacerbation of systemic lupus erythematosusSemantic proximity Read

Regulatory architecture underlying immune dysregulation reconstructed by single-cell multi-omics in lupus nephritisSemantic proximity Read

A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidneySemantic proximity Read

The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell ResolutionSemantic proximity Read

Integrative transcriptomic analysis of SLE reveals IFN-driven cross-talk between immune cellsSemantic proximity Read

Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene ExpressionSemantic proximity Read

Genomic dissection of Systemic Lupus Erythematosus: Distinct Susceptibility, Activity and Severity SignaturesSemantic proximity Read

SLECA: a single-cell atlas of systemic lupus erythematosus enabling rare cell discovery using graph transformerSemantic proximity Read

Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysis.Semantic proximity Read

The Molecular Endotypes of Type 1 and Type 2 SLESemantic proximity Read

Two distinct chromatin modules regulate proinflammatory gene expressionSemantic proximity Read