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Extensive fragmentation and re-organization of transcription in Systemic Lupus Erythematosus

6 Oct 2020

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship between transcriptional deregulation and genome organization remains largely unstudied. In this work...

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PMID: 33024230
DOI: 10.1038/s41598-020-73654-4

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