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Article

Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.

PLoS genetics - 1 Jul 2014

Luo Yunhai, Hartford Suzanne A, Zeng Ruizhu, Southard Teresa L, Shima Naoko, Schimenti John C

Abstract excerpt

Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which arise and propagate during very early stages of mammalian development. Fanconi anemia (FA), a genomic instability syndrome that includes hypogonadism and testicular...

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Identifiers

PMID: 25010009
DOI: 10.1371/journal.pgen.1004471
PMCID: PMC4091704

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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