Article

CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cells development

2022-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Despite our increasing knowledge of molecular mechanisms guiding various aspects of human reproduction, those underlying human primordial germ cell (PGC) development remain largely unknown. Here, we conducted custom CRISPR screening in an in vitro system of hPGC-like cells (hPGCLCs) to identify genes required for acquisition and maintenance of PGC fate in humans. Amongst our candidates, we iden...

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Literature Corpus work: 6e23eab0-dab9-5cdf-b657-326ebfa6bc1a
DOI: 10.1101/2022.05.23.493064

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