Article
MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
Genesis (New York, N.Y. : 2000) - 1 Nov 2015
Luo Yunhai, Schimenti John C
Abstract excerpt
Maintenance of genome integrity is crucial for the germline, and this is reflected by lower mutation rates in gametes than somatic cells. Germ cells at different stages employ different DNA damage response (DDR) mechanisms. In response to certain DNA repair defects, primordial germ cells (PGCs) either undergo apoptosis or delayed proliferation, although little is known about the underlying mechanisms that govern...
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