Article

Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b <sup>+</sup> Leukocytes from Patients with Sepsis

2025-12-18

Abstract excerpt

<h4>Introduction</h4> Sepsis leads to expansion of myeloid-derived suppressor cells (MDSC) and their subtypes. These normally transitory MDSCs suppress T cell activation and alter T cell cytokine production while simultaneously promulgating systemic low-grade inflammation. Immune metabolism can shape cell responses, regulate immune suppression, and enhance effector activity. Although MDSC metabolism has been exte...

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Literature Corpus work: dc7b6c94-6979-5135-b2f0-064022d25945
DOI: 10.64898/2025.12.16.694726

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