Article

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

2025-10-07

Abstract excerpt

<h4>Summary</h4> Sepsis induces profound immune dysregulation, often resulting in chronic critical illness characterized by persistent immunosuppression and poor outcomes. Myeloid-derived suppressor cells (MDSCs) are central mediators of this immunosuppressive phenotype, yet the influence of age and sex on their transcriptional and metabolic states remain poorly understood. Here, we employed single-cell RNA seque...

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Literature Corpus work: d703931b-064b-5230-bfb3-8fcff938b177
DOI: 10.1101/2025.10.06.680736

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