Progression of Peripheral Blood Mononuclear Cell Mitochondrial Function during the Early Phase of Sepsis in Intensive Care Unit Patients

Abstract excerpt

<title>Abstract</title> <p> Background Sepsis is a leading cause of ICU admission and is associated with high rates of multiorgan failure and mortality. Altered mitochondrial function is an essential component of the early sepsis syndrome. However, its progression over time in peripheral blood mononuclear cells (PBMCs), essential mediators of the initial inflammatory response, is thus far unclear. Our purpose wa...

Topics

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• Autophagy in Disease and Therapy
• Clinical Nutrition and Gastroenterology
• COVID-19 Clinical Research Studies
• Immune Response and Inflammation
• Intensive Care Unit Cognitive Disorders
• Mitochondrial Function and Pathology
• Sepsis Diagnosis and Treatment
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

41396acb-b7cf-5256-b570-f4cac078e7a9

DOI

10.21203/rs.3.rs-7137135/v1