Article

Multi-scale characterisation of homologous recombination deficiency in breast cancer

2023-08-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Homologous recombination is a robust, broadly error-free mechanism of double strand break repair, and deficiencies cause reliance on alternative repair processes, leading to sensitivity to PARP inhibitors. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’. However, these patterns are difficult to reliably infer from exome...

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Literature Corpus work: 31e6a0b2-8735-594e-8de2-cd1b70bd19a4
DOI: 10.1101/2023.08.23.554414

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