Article

The germline DNA repair gene landscape in<i>BRCA1</i>and<i>BRCA2</i>implicated hereditary breast cancer families

2025-06-26

Abstract excerpt

<h4>ABSTRACT</h4> As gene-panels expand to include candidate breast cancer predisposing genes (CPGs) involved in diverse DNA repair pathways, we investigated an index breast cancer (BC) case from 56 BRCA1 or BRCA2 implicated high-risk hereditary BC families for rare germline variants predicted to be damaging and clinically relevant in 276 DNA repair genes (DRGs). Using whole exome sequencing analyses, we identifie...

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Literature Corpus work: 493235ab-4323-5a7d-9bf8-58aae4ac3e5a
DOI: 10.1101/2025.06.24.25329575

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