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Article

Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.

The Journal of pathology - 1 Jun 2017

Mutter Robert W, Riaz Nadeem, Ng Charlotte Ky, Delsite Rob, Piscuoglio Salvatore, Edelweiss Marcia, Martelotto Luciano G, Sakr Rita A, King Tari A, Giri Dilip D, Drobnjak Maria, Brogi Edi, Bindra Ranjit, Bernheim Giana, Lim Raymond S, Blecua Pedro, Desrichard Alexis, Higginson Dan, Towers Russell, Jiang Ruomu, Lee William, Weigelt Britta, Reis-Filho Jorge S, Powell Simon N

Abstract excerpt

Homologous recombination (HR) DNA repair-deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be HRD. We developed a functional ex vivo RAD51-based test to identify HRD primary breast cancers. An integrated approach examining methylation, gene expression, and...

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Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Breast Neoplasms, Male

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Source

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Identifiers

PMID: 28299801
DOI: 10.1002/path.4890
PMCID: PMC5516531

Genes

BRCA1
BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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