Article
Transcriptional profiling of Multiple System Atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease
2020-02-12
Abstract excerpt
Multiple system atrophy (MSA) is a rare adult-onset neurodegenerative disease of unknown cause, with no effective therapeutic options, and no cure. Limited work to date has attempted to characterize the transcriptional changes associated with the disease, which presents as either predominating parkinsonian (MSA-P) or cerebellar (MSC-C) symptoms. We report here the results of RNA expression profiling of cerebellar...
Topics
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- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- 3e0978aa-5e2f-5538-8c6a-7385f4b455e9
- DOI
- 10.1101/2020.02.11.944306
