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Article

Inferred Ancestral Origin of Cancer Cell Lines Associates with Differential Drug Response.

International journal of molecular sciences - 20 Sept 2021

Nguyen Phong B H, Ohnmacht Alexander J, Sharifli Samir, Garnett Mathew J, Menden Michael P

Abstract excerpt

Disparities between risk, treatment outcomes and survival rates in cancer patients across the world may be attributed to socioeconomic factors. In addition, the role of ancestry is frequently discussed. In preclinical studies, high-throughput drug screens in cancer cell lines have empowered the identification of clinically relevant molecular biomarkers of drug sensitivity; however, the genetic ancestry from...

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Asian People
Biomarkers, Tumor
Cell Line, Tumor
Drug Resistance, Neoplasm
HLA Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

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PMID: 34576298
DOI: 10.3390/ijms221810135
PMCID: PMC8467551

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