Article

Widespread impact of natural genetic variations in CRISPR/Cas9 outcomes

2023-09-27

Abstract excerpt

CRISPR/Cas9 is a genome editing tool widely used in biological research and clinical therapeutics. Natural human genetic variations, through altering the sequence context of CRISPR/Cas9 target regions, can significantly affect its DNA repair outcomes and ultimately lead to different editing efficiencies. However, these effects have not been systematically studied, even as CRISPR/Cas9 is broadly applied to primary...

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Literature Corpus work: caf4fcf6-aba4-5f98-a665-2416eaecad52
DOI: 10.1101/2023.09.26.559657

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