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Precision oncology and genetic ancestry: The science behind population-based cancer disparities.

Cancer cell - 14 Apr 2025

Davis Melissa Boneta, Martini Rachel

Abstract excerpt

Precision oncology has transformed cancer care but has barely benefited patients of diverse ancestry. Historically, self-reported race/ethnicity has served as a surrogate for biological differences, but genetic ancestry provides a more precise framework for understanding genetic drivers of cancer disparities, including associations between ancestry and tumor subtypes, and genetic variants affecting drug...

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PMID: 40233717
DOI: 10.1016/j.ccell.2025.03.022

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