Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

7 Aug 2012

Abstract excerpt

Mutations in several genes, including Parkin, PTEN-induced kinase 1 (Pink1) and DJ-1, are associated with rare inherited forms of Parkinson's disease (PD). Despite recent attention on the function of these genes, the interplay between DJ-1, Pink1 and Parkin in PD pathogenesis remains unclear. In particular, whether these genes regulate mitochondrial control pathways in neurons is highly controversial. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22872702
DOI: 10.1093/hmg/dds325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neuronsPMID 22872702Read ↗

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.Semantic proximity Read ↗

Parkin and PINK1 functions in oxidative stress and neurodegeneration.Semantic proximity Read ↗

Mitochondrial quality control and dynamics in Parkinson's disease.Semantic proximity Read ↗

A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death.Semantic proximity Read ↗

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.Semantic proximity Read ↗

DJ-1 regulation of mitochondrial function and autophagy through oxidative stressSemantic proximity Read ↗

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.Semantic proximity Read ↗

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.Semantic proximity Read ↗

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s diseaseSemantic proximity Read ↗

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress responseSemantic proximity Read ↗

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate ParkinSemantic proximity Read ↗

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosolSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.