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Article

Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.

Scientific reports - 9 Oct 2017

Matsuda Noriyuki, Kimura Mayumi, Queliconi Bruno Barros, Kojima Waka, Mishima Masaki, Takagi Kenji, Koyano Fumika, Yamano Koji, Mizushima Tsunehiro, Ito Yutaka, Tanaka Keiji

Abstract excerpt

DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD). Consequently, the full elucidation of DJ-1 function will help decipher the molecular mechanisms underlying PD pathogenesis. However, because various, and sometimes inconsistent, roles for DJ-1 have been reported, the molecular function of DJ-1 remains controversial. Recently, a number of papers have...

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Share to Acetylcysteine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inactivation, Metabolic

Share to Protein Deglycase DJ-1

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Source

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Identifiers

PMID: 28993701
DOI: 10.1038/s41598-017-13146-0
PMCID: PMC5634459

Genes

PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.PMID 28993701Read ↗

Parkinsonism-associated protein DJ-1 is a bona fide deglycase.Semantic proximity Read ↗

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Human DJ-1 and its homologs are novel glyoxalasesSemantic proximity Read ↗

Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survivalSemantic proximity Read ↗

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal DetoxificationSemantic proximity Read ↗

Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson's Disease.Semantic proximity Read ↗

Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae.Semantic proximity Read ↗

YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.Semantic proximity Read ↗

Misfolding caused by the pathogenic mutation G47R on the minor allele of alanine:glyoxylate aminotransferase and chaperoning activity of pyridoxine.Semantic proximity Read ↗

Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.Semantic proximity Read ↗

C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of FerroptosisSemantic proximity Read ↗

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