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Human DJ-1 and its homologs are novel glyoxalases

20 Apr 2012

Abstract excerpt

Human DJ-1 is a genetic cause of early-onset Parkinson's disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione. Purified DJ-1 proteins exhibit typical Michaelis-Menten kinetics, which...

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PMID: 22523093
DOI: 10.1093/hmg/dds155

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