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The combination of glycolic acid and D-lactate delays disease progression in SOD-1 ALS mice, partially rescues lethality in iTBPH <sup>pkk(108354)</sup> Drosophila and shows promising results in experimental treatments in two ALS patients

2025-11-14

Abstract excerpt

Amyotrophic Lateral Sclerosis is the most common motor neuron disease. It is incurable and, at the time of this study, only two treatments with a limited therapeutical effect are available: riluzole and edavarone (not in Europe). These treatments have been shown to delay the progression of the disease by a maximum of 10%. We recently showed that glycolic acid (GA) and D-lactate (DL) are able to revert some of the...

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Literature Corpus work
c47f508d-f5b5-5db5-aebd-ac9cbf8c346c
DOI
10.1101/2025.11.07.25334423
Open publication

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The combination of glycolic acid and D-lactate delays disease progression in SOD-1 ALS mice, partially rescues lethality in iTBPH <sup>pkk(108354)</sup> Drosophila and shows promising results in experimental treatments in two ALS patientsDOI 10.1101/2025.11.07.25334423
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