Article

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures

2018-02-01

Abstract excerpt

<h4>SUMMARY</h4> Apart from their antimicrobial properties, tetracyclines demonstrate clinically validated effects in the amelioration of pathological inflammation and human cancer. Delineation of the target(s) and mechanism(s) responsible for these effects, however, has remained elusive. Here, employing quantitative mass spectrometry-based proteomics, we identified human 80S ribosomes as targets of the tetracycl...

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Literature Corpus work: 76208061-aedb-5d7a-9015-335af13ddf85
DOI: 10.1101/256230

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