Article

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

2024-04-03

Abstract excerpt

Stimulation of the innate immune system by foreign RNA elicits a potent response against invading pathogens and can trigger cell death. The mechanisms by which cells balance a robust response with cell-intrinsic lethality are still being uncovered. Employing genome-wide CRISPR-Cas9 genetic screens with triphosphorylated RNA stimulation, we identify speckled protein 110 (SP110) as a potent negative regulator of typ...

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Literature Corpus work: dbffba6a-ab3a-56b6-931e-67874aa145c4
DOI: 10.1101/2024.04.03.587867

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