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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

11 May 2022

Abstract excerpt

The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but are completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily dynamic transcriptional regulation of S100a8 and S100a9 genes, however, are only barely understood. Using an unbiased genome-wide CRISPR/Cas9 knockout (KO)-based screening approach in...

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PMID: 35543413
DOI: 10.7554/elife.75594

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