Article

Pharmacological interrogation of crosstalk between TLR signaling and stress granules reveals a compound with antiviral effect

2025-04-17

Abstract excerpt

Stress granules (SG) are cytoplasmic membraneless compartments that regulate cellular stress responses and have been implicated in antiviral defense against Influenza A Virus (IAV). SG stabilization has been reported to be a viable strategy to develop antiviral drugs. To expand the repertoire of SG-modulating compounds, we performed a targeted pharmacological screen focusing on inhibitors of TLR signaling pathway,...

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Literature Corpus work: f329675c-e58e-53cb-bb1d-72f91a443953
DOI: 10.1101/2025.04.11.648452

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