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Article

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

2020-08-10

Abstract excerpt

Speckled 140 KDa (SP140) is a nuclear body protein, mainly expressed in immune cells, which contains multiple domains suggestive of an epigenetic reader function; namely a bromodomain, a PHD domain and a SAND domain. Single nucleotide polymorphisms and epigenetic modifications in the SP140 locus have been linked to autoimmune and inflammatory diseases including Crohn’s disease (CD). However, little is known about...

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Literature Corpus work
c0a79d3d-765a-5f71-bded-42cd45ddb2e2
DOI
10.1101/2020.08.10.239475
Open publication

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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140DOI 10.1101/2020.08.10.239475
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