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Article

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective

26 Sept 2017

Abstract excerpt

A significant challenge toward studies of the human microbiota involves establishing causal links between bacterial metabolites and human health and disease states. Certain strains of commensal Escherichia coli harbor the 54-kb clb gene cluster which codes for small molecules named precolibactins and colibactins. Several studies suggest colibactins are genotoxins and support a role for clb metabolites in...

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PMID: 28949546
DOI: 10.1021/jacs.7b07807

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Related research

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Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic PerspectivePMID 28949546Read ↗

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Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic PathwaySemantic proximity Read ↗

Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer.Semantic proximity Read ↗

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Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin ASemantic proximity Read ↗

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