Article

Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in HLRCC

2018-04-06

Abstract excerpt

Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is an inherited cancer syndrome associated with a highly aggressive form of type 2 papillary renal cell carcinoma (PRCC). Germ line inactivating alterations in Fumarate Hydratase ( FH ) cause HLRCC, and result in elevated levels of reactive oxygen species (ROS). Recent work indicates that FH -/- PRCC cells have increased ABL1 activation, which promotes tum...

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Literature Corpus work: dbf7d2d4-9a4e-5ca6-8a17-41792247a647
DOI: 10.1101/296194

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