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Article

Differential oxidation of protein-tyrosine phosphatases.

The Journal of biological chemistry - 18 Mar 2005

Groen Arnoud, Lemeer Simone, van der Wijk Thea, Overvoorde John, Heck Albert J R, Ostman Arne, Barford David, Slijper Monique, den Hertog Jeroen

Abstract excerpt

Oxidation is emerging as an important regulatory mechanism of protein-tyrosine phosphatases (PTPs). Here we report that PTPs are differentially oxidized, and we provide evidence for the underlying mechanism. The membrane-proximal RPTPalpha-D1 was catalytically active but not readily oxidized as assessed by immunoprobing with an antibody that recognized oxidized catalytic site cysteines in PTPs (oxPTPs). In...

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PMID: 15623519
DOI: 10.1074/jbc.M412424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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