Article

Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants

2025-03-01

Abstract excerpt

Missense mutations in PTPN11 , which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations could potentially drive pathogenic signaling by altering SHP2 interactions or localization. We employed proximity-la...

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Literature Corpus work: 2bd34f95-be54-50c3-924d-c9f1864f79d3
DOI: 10.1101/2025.02.26.640373

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