Article

Binding of Small Molecule Inhibitors to RNA Polymerase-Spt5 Complex Impacts RNA and DNA Stability

2023-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Spt5 is an elongation factor that associates with RNA polymerase II (Pol II) during transcription and has important functions in promoter-proximal pausing and elongation processivity. Spt5 was also recognized for its roles in the transcription of expanded-repeat genes that are related to neurodegenerative diseases. Recently, a set of Spt5-Pol II small molecule inhibitors (SPIs) were reported, wh...

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Literature Corpus work: dbeb6275-9a71-5ae4-a872-83ad8d21e9fd
DOI: 10.1101/2023.09.12.557491

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