Article

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

2024-06-05

Abstract excerpt

<title>Abstract</title> <p>MicroRNAs (miRNAs) are small non-coding RNAs responsible for RNA silencing and the posttranscriptional regulation of gene expression. Poly(A) RNA polymerase D5 (PAPD5) catalyzes the addition of adenosine to the 3′ end of miRNAs, which promotes their subsequent degradation. In this study, we demonstrated that the Yin Yang 1 (YY1) protein, a transcriptional repressor of PAPD5, was recruit...

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Literature Corpus work: fdfa2c97-b3a2-5548-bd37-579570d75aba
DOI: 10.21203/rs.3.rs-2983878/v1

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