Article

Txn-Txnrd1 system supports redox rewiring during polyaneuploid transition and protects giant cancer cell at new redox homeostasis

2026-08-28

Abstract excerpt

Polyaneuploid giant cells (PGCC), which occur more frequently in TP53-mutant tumors, are recognized as a driver of tumor recurrence and therapy resistance, but the mechanisms supporting their survival remain largely unknown. Our results indicate that polyaneuploid transition and subsequent PGCC maturation in drug-resistant phenotypes are associated with redox rewiring that shifts cellular homeostasis into mild pro...

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Literature Corpus work: 4346e30d-636f-57cc-bae6-781d9986c1f1
DOI: 10.64898/2026.08.27.746985

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Txn-Txnrd1 system supports redox rewiring during polyaneuploid transition and protects giant cancer cell at new redox homeostasisDOI 10.64898/2026.08.27.746985Read

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