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Article

Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer.

Cell reports. Medicine - 17 Oct 2023

Kim YongHwan, Ju Hyein, Yoo Seung-Yeon, Jeong Jinahn, Heo Jinbeom, Lee Seungun, Park Ja-Min, Yoon Sun Young, Jeong Se Un, Lee Jinyoung, Yun HongDuck, Ryu Chae-Min, Lee Jinah, Nam Yun Ji, Kwon Hyungu, Son Jaekyoung, Jeong Gowun, Oh Ji-Hye, Sung Chang Ohk, Jeong Eui Man, An Jaehoon, Won Sungho, Hong Bumsik, Lee Jae Lyun, Cho Yong Mee, Shin Dong-Myung

Abstract excerpt

Radical cystectomy with preoperative cisplatin-based neoadjuvant chemotherapy (NAC) is the standard care for muscle-invasive bladder cancers (MIBCs). However, the complete response rate to this modality remains relatively low, and current clinicopathologic and molecular classifications are inadequate to predict NAC response in patients with MIBC. Here, we demonstrate that dysregulation of the glutathione (GSH)...

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Identifiers

PMID: 37797616
DOI: 10.1016/j.xcrm.2023.101224
PMCID: PMC10591055

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