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Article

GPX4 Defines an Immune-Cold Phenotype and Poor Prognosis in Resected Lung Adenocarcinoma.

Oncology research - 1 Jan 2026

Wang Ganxin, Liu Zhongan, Zhou Tian, Yang Boting, Chen Jiaqin, Chen Jing, Huang Kai, Xu Yunqing, Tang Quan, Yin Xiangqian, Xiao Guangqin, Zhang Sijia

Abstract excerpt

Objectives: Ferroptosis resistance may contribute to tumor progression and immune escape. This study evaluated the prognostic and immunological significance of glutathione peroxidase 4 (GPX4), a core ferroptosis-suppressive enzyme, in surgically resected lung adenocarcinoma. Methods: We retrospectively analyzed 104 patients with primary lung adenocarcinoma who underwent curative resection. GPX4 protein expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42500575
DOI: 10.32604/or.2026.083840
PMCID: PMC13397352

Genes

GPX4
CD4
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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