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ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal-Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities.

Cells - 13 Dec 2024

Larrea Murillo Luis, Sugden Conor J, Ozsvari Bela, Moftakhar Zahra, Hassan Ghada S, Sotgia Federica, Lisanti Michael P

Abstract excerpt

Cancer stem cells (CSCs) account for 0.01 to 2% of the total tumor mass; however, they play a key role in tumor progression, metastasis and resistance to current cancer therapies. The generation and maintenance of CSCs are usually linked to the epithelial-mesenchymal transition (EMT), a dynamic process involved in reprogramming cancer cells towards a more aggressive and motile phenotype with increased stemness...

Topics

Humans
Neoplastic Stem Cells
Breast Neoplasms
Aldehyde Dehydrogenase
Cell Movement
Female
Epithelial-Mesenchymal Transition
Phenotype
Cell Line, Tumor
Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39768151
DOI: 10.3390/cells13242059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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