Article

Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cells

2025-07-16

Abstract excerpt

While most newly synthesized RNA is exported to the cytoplasm, a portion of non-coding RNA is retained in the nucleus and remains highly associated with chromatin. The strong binding of this RNA fraction to insoluble chromatin impairs its recovery in standard transcriptomic studies. Therefore, the landscape and potential functions of chromatin-associated RNAs are poorly understood. Recent studies indicate that chr...

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Literature Corpus work: dbbaf5bd-d5e6-5fa7-a7d5-12e2fc594939
DOI: 10.1101/2025.07.11.664446

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