Article
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2018
Udugama Maheshi, Sanij Elaine, Voon Hsiao P J, Son Jinbae, Hii Linda, Henson Jeremy D, Chan F Lyn, Chang Fiona T M, Liu Yumei, Pearson Richard B, Kalitsis Paul, Mann Jeffrey R, Collas Philippe, Hannan Ross D, Wong Lee H
Abstract excerpt
ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion of ATRX in mouse ES cells leads to selective loss in ribosomal RNA gene (rDNA) copy number....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.