Article

Downregulation of Gene Expression by Alpha Satellite Transcripts

2025-09-11

Abstract excerpt

Satellite DNAs are highly abundant sequences which build functional centromere and pericentromeric heterochromatin in many eukaryotes. Apart from this structural role, their involvement in gene expression modulation has been demonstrated, although the detailed molecular mechanism is still missing. Here, using major human alpha satellite as a model system, we investigate the role of satellite transcripts in gene ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2267682-3a42-52ac-8648-132f8d2ce3e5
DOI: 10.20944/preprints202509.0957.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Downregulation of Gene Expression by Alpha Satellite TranscriptsDOI 10.20944/preprints202509.0957.v1Read

Transcription of tandemly repetitive DNA: functional roles.Semantic proximity Read

Antibiotics induce overexpression of alpha satellite DNA accompanied with epigenetic changes at alpha satellite arrays as well as genome-wideSemantic proximity Read

Functional sequestration of transcription factor activity by repetitive DNA.Semantic proximity Read

Human Satellite 1 (HSAT1) analysis provides novel evidence of pericentromeric transcriptionSemantic proximity Read

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial CancersSemantic proximity Read

HSATII RNA is induced <i>via</i> a non-canonical ATM-regulated DNA-damage response pathway and facilitates tumor cell proliferation and movementSemantic proximity Read

Human Satellite III long non-coding RNA imparts survival benefits to cancer cellsSemantic proximity Read

Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cellsSemantic proximity Read

HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movementSemantic proximity Read

Transcription of the 1.688 satellite DNA family is under the control of RNA interference machinery in Drosophila melanogaster ovaries.Semantic proximity Read

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHDSemantic proximity Read

The implications of satellite DNA instability on cellular function and evolution.Semantic proximity Read