Article

DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways

2024-12-18

Abstract excerpt

<h4>ABSTRACT</h4> RNA-driven protein aggregation leads to cellular dysregulation, disrupting normal cellular processes, and contributing to the development of diseases and tumorigenesis. Here, we show that double homeobox 4 (DUX4), an early embryonic transcription factor and causative gene of facioscapulohumeral muscular dystrophy (FSHD), induces the accumulation of stable intranuclear RNAs, including nucleolar R...

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Literature Corpus work: 94607d44-7140-5c40-8ea0-043ae26bc412
DOI: 10.1101/2024.12.17.628988

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