Article

Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF

2025-11-12

Abstract excerpt

MicroRNAs are ∼22-nucleotide RNAs processed from primary transcripts and exported from the nucleus to repress gene expression by base-pairing to mRNAs. We find that the highest levels of RNA Polymerase II at human microRNA genes are within the ribosomal gene repeat arrays (rDNAs). Alignment of public nascent transcript data to the hs1 human genome assembly reveals a 50-nucleotide transcript for both miR-1275 and m...

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Literature Corpus work: 7d88bb46-c59a-5642-9207-4c837e07dabe
DOI: 10.1101/2025.11.10.687711

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