Article

NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation

2020-11-02

Abstract excerpt

<title>Abstract</title> Deregulation of oncogenic proliferative signals triggers replication stress in cancer cells to which they must adapt1,2. Immediate early genes (IEGs), identified by their rapid stress-induced transient bursts of expression, are critical to integrating downstream signaling pathways3,4. In studying tumor initiation by patient-derived breast cancer cells, we observed...

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Literature Corpus work: db8b7e9e-cd56-5bda-a998-0734bc97d3f9
DOI: 10.21203/rs.3.rs-84947/v1

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