Article
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
Nature communications - 15 Apr 2026
Su Yapeng, Liu Chunmei, Lu Xiang, Chuang Hui-Yu, Li Guideng, Shao Shiqun, Kong Yan, Lee Jihoon W, Ng Rachel H, Wong Stephanie, Robert Lidia, Warden Charles, Liu Victoria, Chen Jie, Wang Zhuo, Qin Guangrong, Tang Yin, Cheng Hanjun, Ng Alphonsus H C, Chen Daniel, Peng Songming, Xue Min, Johnson Dazy, Xu Yu, Wang Jinhui, Wu Xiwei, Shmulevich Ilya, Shi Qihui, Levine Raphael, Ribas Antoni, Baltimore David, Guo Jun, Heath James R, Wei Wei
Abstract excerpt
Drug-induced dedifferentiation towards drug-tolerant persister states is a common mechanism cancer cells exploit to escape therapies, hindering durable responses. How early epigenomic and transcriptomic programs coordinate to initiate these reversible transitions remains largely unexplored. Here we employ high-temporal-resolution multi-omics profiling, information-theoretic approaches, and dynamic system modeling...
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