Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage

11 May 2021

Abstract excerpt

Lack of coordination between the DNA replication and transcription machineries can increase the frequency of transcription-replication conflicts, leading ultimately to DNA damage and genomic instability. A major source of these conflicts is the formation of R-loops, which consist of a transcriptionally generated RNA-DNA hybrid and the displaced single-stranded DNA. R-loops play important physiological roles and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34049076
DOI: 10.1016/j.dnarep.2021.103132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damagePMID 34049076Read ↗

PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integritySemantic proximity Read ↗

PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integritySemantic proximity Read ↗

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral DynamicsSemantic proximity Read ↗

The balancing act of R-loop biology: The good, the bad, and the uglySemantic proximity Read ↗

DNA Topoisomerase I differentially modulates R-loops across the human genomeSemantic proximity Read ↗

Transcriptional regulation mechanism of PARP1 and its application in disease treatmentSemantic proximity Read ↗

Transcription-Coupled Repair and R-Loop Crosstalk in Genome StabilitySemantic proximity Read ↗

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.Semantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

Rewiring DNA repair with PARP-based chemical inducers of proximitySemantic proximity Read ↗

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stressSemantic proximity Read ↗

Clinical and Mechanistic Implications of R-Loops in Human LeukemiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.