Article

USP10 drives cancer stemness and enables super-competitor signalling in Colorectal Cancer

2023-12-19

Abstract excerpt

<title>Abstract</title> <p>The contribution of deubiquitylating enzymes (DUBs) to b-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an unbiassed screen, we discovered that the DUB USP10 stabilizes b-Catenin specifically in APC-truncated CRC <italic>in vitro</italic> and <italic>in vivo</italic>. Mechanistic studies, including <italic>in vitro</it...

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Literature Corpus work: db5e8f4c-f0f4-5712-b60e-6a6b673dc778
DOI: 10.21203/rs.3.rs-3742742/v1

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