Article

USP14 promotes colorectal cancer progression by targeting JNK for stabilization

2022-07-01

Abstract excerpt

<title>Abstract</title> <p>MAPK/JNK signaling is pivotal in carcinogenesis. However, ubiquitin-mediated homeostasis of JNK remains to be verified. Here, with results from RNA sequencing (RNA-seq) and luciferase reporter pathway identification, we show that USP14 orchestrates MAPK/JNK signaling and identify USP14 as a deubiquitinase that interacts and stabilizes JNK. USP14 is elevated in colorectal cancer patients...

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Literature Corpus work: 80c040e9-a8b2-5f91-a048-b5ba59d25e5c
DOI: 10.21203/rs.3.rs-1702021/v1

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