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Article

USP14 promotes colorectal cancer progression by targeting JNK for stabilization

24 Jan 2023

Abstract excerpt

MAPK/JNK signaling is pivotal in carcinogenesis. However, ubiquitin-mediated homeostasis of JNK remains to be verified. Here, with results from RNA sequencing (RNA-seq) and luciferase reporter pathway identification, we show that USP14 orchestrates MAPK/JNK signaling and identify USP14 as a deubiquitinase that interacts and stabilizes JNK. USP14 is elevated in colorectal cancer patients and is positively...

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PMID: 36693850
DOI: 10.1038/s41419-023-05579-5

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