Article

USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer

2024-08-10

Abstract excerpt

<title>Abstract</title> <p>The emerging significance of ubiquitin-specific peptidase 21 (USP21) in stabilizing Fra-1 (FOSL1) has shed light on their involvement in promoting colorectal cancer (CRC) metastasis. Additionally, EGFR signaling has been linked reciprocally with Fra-1 activation in an MMP-dependent manner. However, the functional implications of the USP21-EGFR signaling axis in metastatic CRC (mCRC) rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea4c8a3b-272e-54ec-bc37-f395e964c763
DOI: 10.21203/rs.3.rs-4594251/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancerDOI 10.21203/rs.3.rs-4594251/v1Read

Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 DeubiquitinaseSemantic proximity Read

Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal CarcinomaSemantic proximity Read

USP14 promotes colorectal cancer progression by targeting JNK for stabilizationSemantic proximity Read

USP14 promotes colorectal cancer progression by targeting JNK for stabilizationSemantic proximity Read

USP39 mediates p21‐dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axisSemantic proximity Read

USP18 directly regulates Snail1 protein through ubiquitination pathway in colorectal cancerSemantic proximity Read

Research on the mechanism by which USP18 promotes colorectal cancer progression through stabilizing KRT16 expressionSemantic proximity Read

USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancerSemantic proximity Read

LncRNA USP2-AS1 facilitates colorectal cancer development via upregulating PHLDA2 through recruiting IGF2BP2 and absorbing miR-134-5pSemantic proximity Read

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.Semantic proximity Read

Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Specific Peptidase 11 (USP11) As a Prognostic and Immunological BiomarkerSemantic proximity Read

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read