Article
Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterations in human tumors.
Pathology international - 1 Apr 2009
Suzuki Masaya, Nagura Kiyoko, Igarashi Hisaki, Tao Hong, Midorikawa Yutaka, Kitayama Yasuhiko, Sugimura Haruhiko
Abstract excerpt
The platforms of high-resolution genetic analysis of human tumors have become popular, and several copy number estimation algorithms have been applied to the data generated by single-nucleotide polymorphism microarrays. Although comparisons have been made between several different platforms or methodologies, there has never been a robust comparison of different copy number estimation algorithms, and the validity...
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