Article

Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in senescent cells

2025-11-28

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence, a complex biological process characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype, has emerged as a critical target for therapeutic development for age-related diseases. Ferroptosis, an iron-dependent regulated cell death pathway driven by the accumulation of lipid peroxidation in cell membranes, has been implicated in ne...

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Literature Corpus work: db2b814b-bb60-58a0-804e-89dc9e876a6e
DOI: 10.21203/rs.3.rs-8117957/v1

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