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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

14 Dec 2023

Abstract excerpt

Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report that cellular senescence, and multiple types of fibrotic diseases in mice and humans are characterized by the...

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PMID: 38097808
DOI: 10.1038/s42255-023-00928-2

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